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KMID : 0380319930520010149
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Journal of Korean Research Institute for Better Living
1993 Volume.52 No. 1 p.149 ~ p.164
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Study on Genetic Polymorphism of Human Plasma Protein in Korean Population
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Abstract
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Abstract-To detect genetic polymorphisms of human plasma protein, Apolipoprotein H(APD H), Apolipoprotein D(APO D) and Hemopexin(HPX) in Korean population, the vertical polyacrylamide slab gel isoelectric focusing method was used.
@ES The results were obtained as follows:
@EN 1. The phenotype of APO H is characterized by the most frequent APO 2-2 and two rare phenotypes, 2-1 and 3-2 in Korean population. Other rare phenotypes, 1-1, 3-3, 3-1, and 4-2, were not detected.
2. The frequencies of the three alleles designated APO H*1, APO H*2, and APO H*3 were caculated to be 0.042, 0.942, and 0.017, respectively.
3. Only APO D1-1 type was detected in Korean population. APO D 2-1 was not found in Korean population. The gene frequency of APO D alleles was 1.00.
4. The phenotype of HPX found in Korean population was only HPX 1-1, and other rare phenotypes, 2-1, 3-1, and 3-3 were not found. The gene frequency of HPX alleles also was 1,00.
5. Based on the above results, APO H was polymorphic, but both of the APO D and HPX were monomorphic in Korean population.
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